breast cancer

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Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk

 

Authors and Affiliations:

Ana Jacinta-Fernandes, Joana M. Xavier, Ramiro Magno, Joel G. Lage & Ana-Teresa Maia

Centre for Biomedical Research (CBMR), Algarve Biomedical Center (ABC) and Department of Biomedical Sciences and Medicine (DCBM) Universidade do Algarve, Faro 8005-139, Portugal

 

Abstract:

Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk

Através da adaptação computacional de ferramentas de análise de miRNAs e da integração com dados genómicos de expressão alélica em mama,   identificaram-se genes alvo candidatos e propõe-se a função de variantes genéticas associadas ao risco para cancro da mama. O modelo de análise proposto é ainda passível de ser aplicado ao estudo do risco em outras doenças complexas.

 

Autores e Afiliações:

Ana Jacinta-Fernandes, Joana M. Xavier, Ramiro Magno, Joel G. Lage & Ana-Teresa Maia

6th World Congress on Controversies in Breast Cancer (CoBrCa)

Mercure Hotel MOA Berlin, Germany

 

November 19-21, 2020

 

See more informations here: https://cobrca.org/

6th World Congress on Controversies in Breast Cancer (CoBrCa)

Mercure Hotel MOA Berlin, Germany

 

November 19-21, 2020

 

See more informations here: https://cobrca.org/

Buenos Aires Breast Cancer Symposium 2020

La Usina del Arte, Buenos Aires, Argentina

 

18-21 May, 2020

 

See more informations here: https://ba-bcs2020.com/

Buenos Aires Breast Cancer Symposium 2020

La Usina del Arte, Buenos Aires, Argentina

 

18-21 May, 2020

 

See more informations here: https://ba-bcs2020.com/

Synthesis of Benzophenones and in vitro Evaluation of Their Anticancer Potential in Breast and Prostate Cancer Cells


Lydia Saidi, [b] Djenisa H. A. Rocha, [a][c][e] Oualid Talhi,[a] [d] Yamina Bentarzi,[b] Bellara Nedjar-Kolli,[b] Khaldoun Bachari,[d] Filipe A. Almeida Paz,[e] Luisa A. Helguero,[c] and Artur M. S. Silva[a]

[a] QOPNA and LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro (Portugal)

New hormone-independent growth mechanism in luminal breast cancer


Giulianelli S (1,2), Riggio M (1), Guillardoy T (1), Pérez Piñero C (1), Gorostiaga MA (1), Sequeira G (1), Pataccini G (1), Abascal MF (1), Toledo MF (1), Jacobsen BM (3), Guerreiro AC (4), Barros A (4), Novaro V (1), Monteiro FL (5), Amado F (4), Gass H (6), Abba M (7), Helguero LA* (5), Lanari C* (1). * co-senior authors

(1) Instituto de Biología y Medicina Experimental, IByME-CONICET, Buenos Aires, Argentina.

The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells from different subtypes

Downregulation of DLL1 protein (a ligand of the Notch signaling pathway) decreases the carcinogenic properties of cancer cells from various human breast cancer subtypes in different manners. This study, developed by scientists from iBET, contributes to the knowledge of the mechanisms involved in the pathobiology of breast cancer and to the development of new therapies to target this disease.

 

Authors and Affiliations:

Unfolded Protein Response in breast and prostate cancers


Inês Direito (iBiMED, Aveiro); Margarida Fardilha (iBiMED, Aveiro); Luisa Helguero (iBiMED, Aveiro)