ASPIC

Centro de Investigación del Cáncer, Salamanca (Cancer Research Centre), Spain

12-13 Sptember, 2019

See more informations here: http://www.aseica.es/congreso-aseica/i-aseica-aspic-international-meeting/

A research team led by Cecília Rodrigues, from the Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, has identified a new molecular pathway underlying the maintenance of stem cell-like features in colon cancer cells. This study was published in Cell Death Discovery. The presence of cancer stem cells within tumors, including those from the colon and rectum, is associated with increased therapy resistance and worse clinical outcomes.

Uma equipa de investigação liderada por Cecília Rodrigues, do Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, identificou uma nova via de sinalização celular subjacente à manutenção de características tipo estaminal em células de cancro do cólon. Este estudo foi publicado na revista Cell Death Discovery. A presença de células estaminais cancerígenas entre a massa heterogénea que constitui cada tumor, incluindo os carcinomas colorretais, encontra-se associada à resistência à terapia e a piores taxas de sobrevivência.

It was published an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, it was also adressed the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.

Authors and affiliations:

Salón de actos en Navarrabiomed-FMS, Pamplona, Spain

16 May, 2019

See more informations here: https://onconetmbcb.eu/

Salón de actos en Navarrabiomed-FMS, Pamplona, Spain

16 May, 2019

See more informations here: https://onconetmbcb.eu/

Authors and Affiliations:

Howarth A¹, Madureira PA^1,2, Lockwood G³, Storer LCD³, Grundy R³, Rahman R³, Pilkington GJ¹, Hill R¹.

¹ Brain Tumour Research Centre, Institute of Biomedical and Biomolecular Sciences, IBBS, University of Portsmouth, PO1 2DT, UK

² Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, Portugal

Apesar de décadas de investigação científica o tratamento de gliomas de alto grau pediátrico é ainda muito ineficaz. Como resultado apenas 10-30% das crianças com gliomas de alto grau estão vivas 2 anos após diagnóstico; constituindo desta forma os tumores cerebrais mais agressivos e mais difíceis de tratar em crianças.