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Cancer Vaccines 2014

Holiday Inn Regents Park, London, United Kingdom

 

15- 16 September 2014

 

See more informations here: http://www.smi-online.co.uk/pharmaceuticals/uk/conference/cancer-vaccines

Cancer Vaccines 2014

Holiday Inn Regents Park, London, United Kingdom

 

15- 16 September 2014

 

See more informations here: http://www.smi-online.co.uk/pharmaceuticals/uk/conference/cancer-vaccines

Characterization of Binding Epitopes of CA125 Monoclonal Antibodies

The most used cancer serum biomarker is the CA125 immunoassay for ovarian cancer that detects the mucin MUC16. However, the monoclonal antibodies (OC125 and M11) used in the serum assay have epitopes that remain elusive. In this study, we demonstrate for the first time that neither N- nor O-glycosylation appear to substantially influence binding of OC125 and M11 mAbs and narrowed down the epitopes to a segment containing parts of two consecutive SEA domains with a linker.

Characterization of Binding Epitopes of CA125 Monoclonal Antibodies

The most used cancer serum biomarker is the CA125 immunoassay for ovarian cancer that detects the mucin MUC16. However, the monoclonal antibodies (OC125 and M11) used in the serum assay have epitopes that remain elusive. In this study, we demonstrate for the first time that neither N- nor O-glycosylation appear to substantially influence binding of OC125 and M11 mAbs and narrowed down the epitopes to a segment containing parts of two consecutive SEA domains with a linker.

StemCellNet: A new and unique resource to decipher molecular networks in stem cell biology

In recent years, numerous scientific breakthroughs have expanded our knowledge of stem cell biology, and inspired intense research efforts in this field. Aside from the evident importance of stem cells in developmental processes, their potential for clinical and medical applications has attracted much interest.

StemCellNet: Uma nova ferramenta para decifrar as redes moleculares de células estaminais

Nos últimos anos vários avanços científicos têm contribuído para a expansão do nosso conhecimento acerca das células estaminais, e para o aumento do interesse e investigação nesta área cientifica. Este interesse é motivado não só pela importância das células estaminais no processo de desenvolvimento embrionário, mas também pelo seu potencial em termos de investigação clínica e aplicações médicas.

Tumor cells present a dynamic expression of galectins during metastasis

A group of researchers from IPATIMUP found that the differential expression of galectin-1 and galectin-3 participates in the process of metastasis in a spontaneous canine model of breast cancer.

 

Authors and Affiliations:

Joana T. de Oliveira1,2,3, Augusto J. de Matos2, Rita Barros1, Cláudia Ribeiro1, Asaf Chen1, Venceslau Hespanhol4, Gerard R Rutteman5,6 and Fátima Gärtner1,2

As células tumorais apresentam uma expressão dinâmica de galectinas durante o processo de metastização

Um grupo de investigadores do Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) e do Instituto de Ciências Biomédicas Abel Salazar (ICBAS) desenvolveu um estudo sobre a metastização em tumores mamários caninos, estruturado por Joana Tavares de Oliveira e Fátima Gärtner. Teve como objetivo a pesquisa de potenciais marcadores que pudessem levar a novas terapias, para além da cirurgia que constitui, ainda, o único modo de tratamento considerado eficaz nesta espécie.

EurocanPlatform Translational Cancer Research Course

Hotel Porto Bay, Falésia, Algarve, Portugal

 

20-24 October, 2014

 

See more informations here: http://eurocanplatform.eu/news.php

EurocanPlatform Translational Cancer Research Course

Hotel Porto Bay, Falésia, Algarve, Portugal

 

20-24 October, 2014

 

See more informations here: http://eurocanplatform.eu/news.php