prostate adenocarcinoma

Portuguese researchers unravelled the anticancer activity of the human neutrophil peptide-1, HNP-1, on prostate adenocarcinoma and leukemia cells. This study, recently published in Biochimica et Biophysica Acta – Molecular Cell Research Journal, combines spectroscopic techniques and atomic force microscopy (AFM) for elucidating the peptide’s mode of action and determining potential factors contributing for the peptide’s selective activity toward prostate tumor cells.

Researchers from the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI), which previously described the calcium-binding protein, Regucalcin (RGN), as an underexpressed gene in prostate adenocarcinoma comparatively to non-neoplastic prostate or benign prostate hyperplasia cases, developed a study aiming at investigate the role of this protein in the modulation of cell cycle and apoptosis pathways in rat prostate.