Mitochondria

Authors and Affiliations:

José Teixeira^1,2, Ricardo Amorim¹, Katia Santos², Pedro Soares¹, Sandipan Datta³, Gino A. Cortopassi³, Teresa L. Serafim², Vilma A. Sardão², Jorge Garrido^1,4, Fernanda Borges¹, Paulo J. Oliveira²

¹ CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal

The cell death is regulated by mitochondria. For high concentrations, betulinic acid disrupts mitochondrial function leading cancer cells to death. Therefore, in the present work, we have altered the main structure of betulinic acid in order to increase the efficacy to kill tumor cells. The new molecules promote the death of breast cancer cells, which showed to be not toxic to normal counterparts.

Authors and Affiliations:

Nobel Forum - Stockholm, Sweden

10 – 12 October 2013

See more informations here: http://events.embo.org/13-mac/

Nobel Forum - Stockholm, Sweden

10 – 12 October 2013

See more informations here: http://events.embo.org/13-mac/