microvesicle

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Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells

Extracellular vesicles (EVs) are released from all cells, being not only relevant for physiological processes but also for pathological processes such as cancer. Different types of EVs, including exosomes and microvesicles, have different intracellular origin and biogenesis (exosomes have endosomal origin and smaller sizes while microvesicles have a plasma membrane origin and bigger sizes). EVs may carry different types of molecules from the donor cells, such as proteins and microRNAs.