microenvironment

This review covers the findings related to alterations in the tumor microenvironment induced by KRAS activation in cancer cells, bringing to attention new mechanisms of KRAS-induced tumor progression which may have a great impact on the design of new therapies that target cancer cells by abrogating their interaction with the tumor microenvironment.

Authors and Affiliations:

In the context of the multidisciplinary research project CancerSys - Multiscale modeling for personalized therapy of bone metastasis, financed by FCT and involving the institutions IDMEC, INESC-ID, IT (Instituto Superior Técnico, Universidade de Lisboa), Hospital de Santa Maria and IMM, a dynamic computational model capable of representing the biochemical aspects of bone metastases growth and the effect of the therapies used in this disease.