Margarida Rei

A team of researchers from Instituto de Medicina Molecular (IMM) has uncovered an unexpected cellular cross-talk behind ovarian cancer growth that can be exploited as a novel therapeutic target for future immuno-oncology strategies. The work reveals that gamma delta (γδ) T lymphocytes, which are normally seen as anti-tumour, can, surprisingly, promote tumour growth in ovarian cancer. The research, led by Prof. Bruno Silva-Santos, has now been published in PNAS (Proceedings of the Natural Academy of Sciences of the USA).

Investigadores do Instituto de Medicina Molecular (IMM) descobriram um novo mecanismo imunitário envolvido na progressão do cancro de ovário. O estudo mostra que a comunicação entre dois tipos de células do sistema imunitário – os linfócitos T gama-delta (γδ) e os macrófagos – promove a proliferação de células de cancro de ovário na cavidade peritoneal.