The stem cell factor (SCF) and its tyrosine kinase receptor c-KIT have been implicated in the carcinogenesis of male and female reproductive tissues. Also, several studies have reported that the tissue expression levels of SCF/c-KIT system, which is involved in the control of biological processes, such as apoptosis, cell survival, differentiation, and migration, is controlled by hormones. In this scenario, it is reasonable to question if deregulated hormone actions disturbing the SCF/c-KIT expression can be a relevant step towards carcinogenesis.
