bladder cancer

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Proteome profiling of urine with mass spectrometry approaches and bioinformatic tools allows an integrative perspective of the biological processes modulated by urothelial carcinoma

Using a well-established animal model of urothelial carcinoma, we performed urine proteome profiling from healthy animals and animals with urothelial carcinoma at two time-points of disease pathogenesis. Data analysis highlighted the biological processes involved in disease pathogenesis such as, for instance, response to selenium and to drugs, neutral lipid metabolism at earlier stages of disease, and inflammation, immune response and wound healing at advanced stages.

 

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Sialyl-Tn antigen (STn), which covers bladder cancer cells, contributes to the immune escape of these cells

Tumor cells often have aberrant post-translational modifications of their proteins. In bladder cancer, one of these modifications is the sialyl-Tn (STn) glycan, which is not expressed by normal cells and is highly expressed in high-grade bladder cancer cells. It is known that the immune response is affected by tumor cells, promoting tumor progression. However, little is known about the role of STn in the immune response and its influence on immune cells. Dendritic cells (DCs) play a crucial role in the immune response against tumor cells.

Porphyrin conjugated with monoclonal antibody anti-CD104 is a potential photosensitizer for bladder cancer treatment

Photodynamic therapy (PDT) is a promising method, which has been studied and applied to improve the treatment of several tumour types. PDT combines molecular oxygen, light and a photosensitizer (PS) to generate cytotoxic reactions in cancer cells. The potential of PSs conjugated with biomolecules which will be recognized by antigens or receptors overexpressed in cancer cells prompted us to synthesize and to validate the photodynamic activity of a porphyrin conjugated with human and bovine serum albumins, and the monoclonal antibody anti-CD104.