Alexandre Barros

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Application of biodegradable ureteral stents as delivery vehicles for anti-cancer drugs in the treatment of upper urinary tract urothelial carcinoma

Drug eluting stents can release locally pharmaceutical active ingredients, particularly in the ureter and bladder, increasing the bioavailability and efficacy of the drugs. Although drug eluting stents has been widely used and commercially available in other fields, such as cardiology, its role in urology is limited. In his work, we propose the production of biodegradable stents using a simple technology, developed and patented by the team as drug new drug delivery devices, namely for the delivery of anti-cancer drugs for the treatment of upper urinary tract urothelial carcinoma.

Aplicação de cateteres ureterais biodegradáveis como veículos de libertação de fármacos para o tratamento de tumores do tracto superior do ureter

Os cateteres farmacológicos podem libertar compostos ativos que agem localmente no ureter ou bexiga aumentando assim a sua biodisponibilidade e eficiência. Embora a tecnologia com libertação de fármacos de cateteres esteja já comercialmente disponível noutros campos, tais como na cardiologia, o seu papel na urologia tem sido limitado.