Identification of 23 new prostate cancer susceptibility loci

Authors and affiliations:
Rosalind A Eeles, (...) Manuel R. Teixeira, (...) Sofia Maia, Paula Paulo, (...) The PRACTICAL Consortium, Zsofia Kote-Jarai, Douglas F Easton (...)

The number of authors and affilliations is very high so it's better to see the original publication: http://www.nature.com/ng/journal/v45/n4/full/ng.2560.html

Abstract:
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ~30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Journal:
Nature Genetics, 45(4):385-91, 2013.

Link:
http://www.nature.com/ng/journal/v45/n4/full/ng.2560.html