renal cancer

Clear cell renal cell carcinoma (ccCCR) is the most common type (~70%) of renal cancer, having a generally asymptomatic development and risk of systemic progression. Thus, the discovery of more sensitive and specific biomarkers for early detection and more effective treatment becomes urgent. The Research Group of UCIBIO-REQUIMTE - Toxicology Laboratory of the Faculty of Pharmacy of the University of Porto, in collaboration with the Portuguese Institute of Oncology of Porto, has carried out research in the area of ​​metabolomics applied to renal cancer.

Rutin is a bioflavonoid widely found in nature that has shown several promising pharmacological properties, including antitumor activity. However, the low solubility of this compound remains one of the limiting factors of its applicability. In the published article “Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells”, the antitumor activity of rutin was demonstrated in 786-O cells, an in vitro model of human renal carcinoma, in which this activity had not yet been studied.