P-glycoprotein

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Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells


Angela Paterna1, Annamária Kincses2, Gabriella Spengler2, Silva Mulhovo3, Joseph Molnár2, Maria-José U. Ferreira1*

1 Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal

2 Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary

Macrocyclic diterpenes of natural origin are able to reverse multidrug resistance in cancer

Authors and Affiliations:
Mariana Alves Reisa, Omar Bauomy Ahmedb, Gabriella Spenglerc, Joseph Molnárc, Hermann Lageb,d and Maria-José U Ferreiraa

a Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenue Prof. Gama Pinto, 1649-003 Lisbon, Portugal

b Institute of Pathology, University Hospital Charité, 10117 Berlin, Germany