Mitochondrial DNA mutation

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A mitochondrial DNA mutation, causing mitochondrial oxidative phosphorylation deficiency, modifies cancer cells’ properties

A research group from Ipatimup discovered that, when a cancer cell harbours a deficiency in oxidative phosphorylation, this increases their ability to move and migrate, as well as their ability to form tumours and metastasis in mice. These effects seem to be mediated by a change in cell-matrix adhesion capacity.