Considerable attempts have been made to produce adequate matrices or scaffolds that mimic bone ECM for applications in tissue engineering and regenerative medicine. In this context, several factors must be considered, such as the modification of biomaterial surfaces using growth factors, living bone cells or proteins, to guide cellular responses in bone remodeling, like osteoblast adhesion and long term functionality expressed as proliferation, synthesis of alkaline phosphatase and deposition of calcium containing mineral.
Considerable attempts have been made to produce adequate matrices or scaffolds that mimic bone ECM for applications in tissue engineering and regenerative medicine. In this context, several factors must be considered, such as the modification of biomaterial surfaces using growth factors, living bone cells or proteins, to guide cellular responses in bone remodeling, like osteoblast adhesion and long term functionality expressed as proliferation, synthesis of alkaline phosphatase and deposition of calcium containing mineral.
Uma proporção significativa de regulação genética é de natureza pós-transcricional, actuando ao nível do processamento, localização, tradução e degradação do ARN. A alteração nos níveis de expressão e/ou actividade das proteínas de ligação ao ARN, factores-chave envolvidos nestes processos de controlo, encontra-se subjacente a diversas patologias, incluindo no cancro.
An international team of investigators, including Portuguese scientists Carlos Caldas and Samuel Aparício identified, by studying the genome of 7000 patients, more than 20 mutational signatures that lead to the 30 more common cancer types. This study was published in Nature and contains information that will help to understand cancer aetiology and development and also to improve prevention and treatment strategies.
