Cellular glycosylation occurring during cancer development and progression represent key features of tumor cell malignant behavior. In this publication, the authors preview and discuss the findings of Nguyen et al. (Cancer Cell. 2017 Nov 13;32(5):639-653) who identified a molecular mechanism in which the relocation of a glycosyltransferase mediating protein O-glycosylation initiation, from the Golgi to endoplasmic reticulum, leads to aberrant glycosylation.
