Bruno M. Simões

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Targeting STAT3 inhibits endocrine resistant stem cells in ER+ breast cancer

Over the last 15 years my research work has been focused in understanding the molecular mechanisms that govern normal and breast cancer stem cells (CSCs). My ultimate goal has always been to translate basic discoveries to clinical applications that can in the long term directly impact on patient care and contribute to a reduction in breast cancer mortality. This work epitomizes this translational research idea because it was pivotal to establishing the grounds for a phase 2 clinical trial on metastatic breast cancer.

Targeting STAT3 inhibits endocrine resistant stem cells in ER+ breast cancer

Over the last 15 years my research work has been focused in understanding the molecular mechanisms that govern normal and breast cancer stem cells (CSCs). My ultimate goal has always been to translate basic discoveries to clinical applications that can in the long term directly impact on patient care and contribute to a reduction in breast cancer mortality. This work epitomizes this translational research idea because it was pivotal to establishing the grounds for a phase 2 clinical trial on metastatic breast cancer.