Regucalcin

The research team of the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI) led by Sílvia Socorro, together with other international researchers, has been publishing several studies aiming at clarifying the role of the calcium-binding protein Regucalcin (RGN) in the regulation of physiology (and pathophysiology) of various tissues and organs.

Researchers from the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI) previously established the role of Regucalcin (RGN) in the control of cell survival and proliferation in prostate, and demonstrated that RGN is a protein underexpressed in prostate cancer cases. Now these researchers evaluated the effect of RGN on aging, a well-known risk factor for the development of prostate cancer. Making use of knock-in animals for RGN, the impact of RGN overexpression in cell aging was determined in what concerns cell proliferation, apoptosis and oxidative stress.

Researchers from the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI), which previously described the calcium-binding protein, Regucalcin (RGN), as an underexpressed gene in prostate adenocarcinoma comparatively to non-neoplastic prostate or benign prostate hyperplasia cases, developed a study aiming at investigate the role of this protein in the modulation of cell cycle and apoptosis pathways in rat prostate.