cell migration and invasion

The human apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional DNA repair enzyme with relevant redox signalling functions. In this paper entitled “The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel”, the quinone derivative E3330, a redox inhibitor of APE1, decreased the colony formation and chemoinvasion of docetaxel-treated MDA-MB-231 cells. In addition, E3330 as single agent significantly reduced the collective cell migration.

A endonuclease apurínica/apirimidínica 1 (APE1) é uma enzima de reparação do DNA multifuncional com funções relevantes na sinalização redox. Neste artigo intitulado “The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel”, o composto E3330, uma quinona que atua como inibidor da função redox da APE1, levou ao decréscimo da formação de colónias e da quimio-invasão de células MDA-MB-231 tratadas com docetaxel.