ASPIC

Churchill College, University of Cambridge, Cambridge, United Kingdom

30 March - 1 April 2020

See more informations here: https://www.eacr.org/conference/dnadamage2020?utm_source=eacrnews&utm_medium=email&utm_campaign=DDR20&utm_content=banner

Centro Congressi Giovanni XXIII, Bergamo, Italy 

12 - 14 February 2020

See more informations here: https://www.eacr.org/conference/lifeordeath2020?utm_source=eacrnews&utm_medium=web&utm_campaign=MLD20&utm_content=banner

Centro Congressi Giovanni XXIII, Bergamo, Italy 

12 - 14 February 2020

See more informations here: https://www.eacr.org/conference/lifeordeath2020?utm_source=eacrnews&utm_medium=web&utm_campaign=MLD20&utm_content=banner

Authors and affiliations:
Ramon Andrade de Mello, MD, PhD, FACP ^1,2 Florian Lordick, MD, PhD ³ Kei Muro, MD, PhD ⁴ Yelena Janjigian, MD ⁵

¹ Algarve Biomedical Centre/Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

² Division of Medical Oncology, School of Medicine, Nove de Julho University, Bauru Campus, São Paulo, Brazil

³ University Cancer Center, Leipzig, Germany

Authors and Affiliations:

Ana Cláudia Santos^1,2§*, Irina Pereira^1,2§, Mariana Magalhães^1,2, Miguel Pereira-Silva¹, Mariana Caldas^1, Laura Ferreira¹, Ana Figueiras^1,2, António J. Ribeiro^1,3, Francisco Veiga^1,2

¹ Departamento de Tecnologia Farmacêutica da Faculdade de Farmácia da Universidade de Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal

O resveratrol (RSV) é um polifenol dotado de potenciais efeitos terapêuticos em doenças crónicas, particularmente no cancro, a segunda principal causa de morte mundial do século vinte e um. A aplicação da nanotecnologia para efeitos de administração de medicamentos permite superar as restrições associadas aos tratamentos anticancerígenos convencionais, particularmente em relação à quimioterapia, permitindo reduzir efeitos adversos, eliminando riscos e ultrapassando os fenómenos de multirresistência aos fármacos.

CD44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O-glycan truncation on CD44 we have analysed glycoengineered cancer cell models displaying shortened O-glycans. Here, we demonstrate that induction of aberrant O-glycan termination through various molecular mechanisms affects CD44 molecular features.

Os glicanos são estruturas polissacarídeas ligadas a proteínas ou lípidos que modificam as propriedades bioquímicas destas macromoléculas a nível estrutural e funcional. Em diversas patologias, perturbações nas vias de biosíntese da glicosilação podem levar à expressão de glicanos aberrantes, alterando funções de diversas proteínas. No cancro, estas estruturas podem conferir fenótipos agressivos como, por exemplo, invasão e migração.

Downregulation of DLL1 protein (a ligand of the Notch signaling pathway) decreases the carcinogenic properties of cancer cells from various human breast cancer subtypes in different manners. This study, developed by scientists from iBET, contributes to the knowledge of the mechanisms involved in the pathobiology of breast cancer and to the development of new therapies to target this disease.

Authors and Affiliations: