cancer

KRUMERS ALPIN Resort & SPA, Seefeld, Tyrol, Austria

11 - 15 December, 2018

See more informations here: https://www.csc-conference.at/

KRUMERS ALPIN Resort & SPA, Seefeld, Tyrol, Austria

11 - 15 December, 2018

See more informations here: https://www.csc-conference.at/

Authors and Afilliations:

Ana Rute Costa^a, Pedro Moura-Ferreira^b, Nuno Lunet^a,c

^a EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal

^b Instituto de Ciências Sociais, Universidade de Lisboa, Lisboa, Portugal

^c Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

Authors and affiliations:
José Machado Lopes ¹, Francisco Rocha Gonçalves ¹, Marina Borges ^1,2, Patrícia Redondo ¹ e José Laranja-Pontes ¹

¹ Portuguese Institute of Oncology at Porto (IPO Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal

Authors and Affiliations:

Gouveia MJ^1,2, Pakharukova MY^3,4, Laha T^5,6,7, Sripa B^5,6,7, Maksimova GA³, Rinaldi G⁸, Brindley PJ⁸, Mordvinov VA^3,9, Amaro T¹⁰, Santos LL¹⁰, Costa JMCD^1,11, Vale N^2,12.

¹ Center for the Study in Animal Science, ICETA, University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal.

Autores e Afiliações:

Gouveia MJ^1,2, Pakharukova MY^3,4, Laha T^5,6,7, Sripa B^5,6,7, Maksimova GA³, Rinaldi G⁸, Brindley PJ⁸, Mordvinov VA^3,9, Amaro T¹⁰, Santos LL¹⁰, Costa JMCD^1,11, Vale N^2,12.

¹ Center for the Study in Animal Science, ICETA, University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal.

Cancer survival improvements in the north region of Portugal during the 2001-2010 were not universal for all cancer sites. A significant increase in net survival was observed for stomach, colon, pancreas, larynx, melanoma, breast, brain and central nervous system, thyroid, non-Hodgkin lymphoma and multiple myeloma. No significant changes in survival were found for gynaecological tumours neither for oesophagus, rectum, liver, prostate, kidney and bladder cancer.

Cancer multidrug resistance (MDR) is a major cause of therapeutic failure in cancer. MDR is mainly due to the overexpression of drug efflux pumps, such as P-glycoprotein (P-gp). Besides overexpression of drug efflux pumps, other molecular mechanisms are involved in the MDR phenotype, including metabolic alterations. Indeed, recent studies showed that it is possible to revert the MDR phenotype by inhibition of glycolysis with specific modulators.

De Rode Hoed’s Great Hall, Amsterdam, Netherlands

4 - 6 June 2018

See more informations here: http://www.eacr.org/conference/molecularpathology2018