A research team from the Center for Neuroscience and Cell Biology, University of Coimbra, developed a targeted lipid-based nanosystem for specific nucleic acid delivery to glioma cells. The exposure of glioma cells to nanoparticles encapsulating anti-microRNA-21 oligonucleotides enhanced the anti-tumoral effect of the anti-angiogenic drug sunitinib. Moreover, increased particle accumulation was found after therapeutic intravenous administration, in a mouse model of glioma.
