Associação Portuguesa de Investigação em Cancro
Bringing vascularization into glioblastoma in vitro models
Bringing vascularization into glioblastoma in vitro models
Authors and Affiliations:
Catarina Pacheco1,2,3, Fátima Baltazar4,5, Bruno M. Costa4,5, Bruno Sarmento 1,2,3
1i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal
2INEB – Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal
3UNIPRO – Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal
4Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
5ICVS/3Bs-PT Government Associate Laboratory, Braga/Guimaraes, Portugal
Abstract:
Tumor blood vessels create optimal conditions for glioblastoma (GBM) growth and therapy resistance. Therefore, tissue engineering techniques evolved towards allowing its inclusion in preclinical in vitro GBM models. In comparison with conventional ones, less representative of tumor biology, these new tools might significantly improve GBM treatment, contributing to a higher throughput screening in drug research and to the clinical translation of these therapies.
Jounal: Trends in Molecular Medicine
