antiproliferative activity

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Manganese complexes as an alternative to platinum in cancer therapy

The health of the population is crucial for the development of society. Unfortunately, current health systems are under increasing pressure, greatly aggravated by the Covid-19 pandemic, which, consequently, has made the work of health professionals in the field of oncology difficult. Cancer is the second leading cause of death worldwide and it is estimated that in 2040 there will be 28.4 million new cases of cancer worldwide.

Complexos de manganês como alternativa aos de platina na terapêutica do cancro

A saúde da população é crucial para o desenvolvimento da sociedade. Infelizmente, os sistemas de saúde actuais estão sob crescente pressão, muito agravada pela pandemia de Covid-19 que, consequentemente, veio dificultar o trabalho aos profissionais de saúde na área da oncologia. O cancro é a segunda causa de morte a nível mundial e estima-se que em 2040 ocorrerão 28,4 milhões de novos casos de cancro em todo o mundo.

V181A and R68G as putative markers of cynaropicrin content related to antiproliferative activity of breast cancer cells

Researchers at the Centre of Agronomic and Agro-Industrial Biotechnology of Alentejo (CEBAL) in Beja identified, in a natural population of Cynara cardunculus, two allelic variants in GAS (Germacrene A Synthase) gene sequence with significant associations between the cynaropicrin content (a lactone sesquiterpene) and the antiproliferative activity of a breast cancer cell line (MDA-MD-231), in vitro.