antidiabetic drugs

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Anticancer potential of combined antidiabetic drugs in pancreatic cancer treatment

Despite significant advances in the understanding, prevention, diagnosis and treatment of pancreatic cancer, it continues to affect millions of people around the world. People with diabetes have an increased lifetime risk of developing pancreatic cancer. Sodium-glucose co-transporter 2 (SGLT2) inhibitors and metformin are drugs widely used to treat type 2 diabetes, and both have been associated with a reduction in the risk of pancreatic cancer.

The block of the lactate transport and antidiabetic drugs inhibit tumor

Sara Granja 1,2, Ibtissam Marchiq 3, Renaud Le Floch 3, Conceição Souto Moura 5,6, Fátima Baltazar 1,2,* and Jacques Pouysségur 3,4

1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

2 ICVS/3B’s-PT Government Associate Laboratory, Braga/ Guimarães, Portugal