Angiogenesis

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Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

Authors and Affiliations:

Ana P. Cardoso1,2,3, Marta L. Pinto1,2,4, Ana T. Pinto1,2,3, Marta T. Pinto1,4, Cátia Monteiro1,2, Marta I. Oliveira1,2, Susana G. Santos1,2,3, João B. Relvas1,5, Raquel Seruca1,6,7, Alberto Mantovani8,9, Marc Mareel10, Mário A. Barbosa1,2,4 and Maria J. Oliveira1,2,7

1I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Metaloproteases de matriz como maestros do duplo papel de macrófagos pró-inflamatórios e anti-inflamatórios no comportamento de células tumorais

No microambiente do tumor, as células tumorais interagem com outras populações celulares, das quais se destacam as células do sistema imune. De entre estas, destacam-se os macrófagos que se podem diferenciar em várias populações com diferentes perfis inflamatórios. No entanto, o seu papel na atividade das células tumorais é ainda pouco conhecido.