Cancer mortality reduction remains a major societal goal, in part materialized in the many efforts to develop effective biomarkers for early detection. Early detection of renal cell carcinoma (RCC) significantly increases the likelihood of curative treatment, avoiding the need for subsequent therapies, which have side effect and entail more comorbidities. Thus, the research team from Portuguese Oncology Institute of Porto/ Porto Comprehensive Cancer Centre and University of Porto unveiled and validated a panel of 4 circulating miRNAs for detection of RCC, using droplet digital PCR.