In this work we have assessed the expression profile of two transcription factors, SOX2 and CDX2 in intestinal metaplasia (IM) and dysplasia, two lesions that precede gastric cancer onset. Our results provide a molecular basis to understand the heterogeneity of metaplastic lesions and favor the hypothesis that dysplasia arises from IM. These results have clinical implications since they advise a closer surveillance of patients presenting with IM.
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