This study, performed by a group of investigators at IPATIMUP and published in Laboratory Investigation, identified the marker of intestinal differentiation CDX2 as a modulator of the glycoproteome in intestinal metaplasia, a precursor lesion of gastric cancer characterized by a transdifferentiation of the gastric mucosa into intestinal mucosa. The study showed that CDX2 transcription factor directly regulates ST6GalNAc-I gene in intestinal metaplasia lesions.
