Rita Pinto

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Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression

In this study, the authors combined the use of genome editing tools and last generation inducible systems in order to develop a cell model where the expression of CDX2 transcription factor can be tightly regulated. CDX2 is an intestinal differentiation marker whose expression is often altered in gastric and colon carcinomas. Its control was here shown to be useful to uncover novel putative downstream effector genes (such as GPA33 and LDLR), and therefore, to further clarify the role of CDX2 in intestinal cells.

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression

In this study, the authors combined the use of genome editing tools and last generation inducible systems in order to develop a cell model where the expression of CDX2 transcription factor can be tightly regulated. CDX2 is an intestinal differentiation marker whose expression is often altered in gastric and colon carcinomas. Its control was here shown to be useful to uncover novel putative downstream effector genes (such as GPA33 and LDLR), and therefore, to further clarify the role of CDX2 in intestinal cells.

CDX2 homeoprotein regulates ST6GalNAc-I in intestinal metaplasia

This study, performed by a group of investigators at IPATIMUP and published in Laboratory Investigation, identified the marker of intestinal differentiation CDX2 as a modulator of the glycoproteome in intestinal metaplasia, a precursor lesion of gastric cancer characterized by a transdifferentiation of the gastric mucosa into intestinal mucosa. The study showed that CDX2 transcription factor directly regulates ST6GalNAc-I gene in intestinal metaplasia lesions.

O factor de transcrição CDX2 está envolvido na regulação da ST6GalNAc-I em metaplasia intestinal

Este estudo, realizado por um grupo de investigadores do IPATIMUP e publicado na revista Laboratory Investigation, identificou o marcador de diferenciação intestinal CDX2 como um modulador do glicoproteoma na metaplasia intestinal, uma lesão precursora de cancro gástrico que se caracteriza por uma transdiferenciação da mucosa gástrica em mucosa intestinal. O estudo mostrou que o factor de transcrição CDX2 regula directamente o gene da ST6GalNAc-I em lesões de metaplasia intestinal.