This review summarizes the current knowledge on the molecular mechanisms underlying the acquisition of microsatellite instability (MSI) in gastric cancer (GC) as well as on the clinic, pathologic and molecular consequences of the MSI phenotype. Additionally, current therapeutic strategies for GC and their applicability in the MSI subset are also discussed.
Authors and Affiliations:
Sérgia Velho*, Maria Sofia Fernandes*, Marina Leite, Ceu Figueiredo, Raquel Seruca
* authors contributed equally to this paper