malignant brain tumour

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Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Gliomas are the most common and malignant brain tumors.. Due to their high infiltrative and invasive capacity into adjacent tissues, these tumors are extremely difficult to be completely resected during surgery, leading to tumor recurrence, and ultimately patient death. Therefore, the knowledge of the molecular mechanisms associated with cancer invasion process is crucial to prevent this phenomena, thus increasing the survival of gliomas patients. ,