In this study, which included 684 patients with invasive breast carcinoma and long-term follow-up, we observed that those who presented grade 1 and grade 2 aneuploid tumours, as compared with diploid ones, had worse prognosis, either in the whole series or in early breast cancer (stages I/IIA of disease). The finding has therapeutic implications, as these patients are potential candidates to risk-adapted adjuvant therapy.
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