The mechanical properties of cells and extracellular environment, in particular their stiffness and adhesion capacity, are important in the early stages of bladder cancer initiation. A computational model, developed at the University of Coimbra, describes the different layers of the urothelium and allows to study which characteristics are most relevant to the invasive capacity of neighboring tissues by tumor cells. This work provides useful indications for the development of alternative therapeutic strategies.
Authors and Affiliations:
