TERT promoter

Prostate cancer (PC) is the most common cancer in the male population with a high prevalence from 60 years old. Despite the high prevalence, mortality rates are variable and reflect the heterogeneous nature (clinical and biological) of this disease. Recent studies have shown that most patients with low-risk disease do not need treatment. However, in this apparently homogeneous group, there are patients who have aggressive disease - and benefit from therapy.

Authors and Affiliations:

A team of IPATIMUP researchers had previously demonstrated that alterations in the telomerase gene are common to different types of cancer, including tumors of the skin, brain, bladder, and thyroid and are associated with increased levels of this enzyme in tumors. The same team now published a study in Journal of Investigative Dermatology, where they analyzed two types of skin cancer, melanoma and basal cell carcinoma, and demonstrates that telomerase gene mutations are associated with sun exposure and are also associated with a poorer prognosis in melanoma.

Authors and affiliations:

Castelo-Branco P (a) , Choufani S (b), Mack S (a), Gallagher D (c), Zhang C (a), Lipman T (a), Zhukova N (a) , Walker EJ(a), Martin D (a), Merino D (b), Wasserman JD (b), Elizabeth C(a), Alon N (b), Zhang L (d), Hovestadt V (e), Kool M (f), Jones DT (f), Zadeh G (a), Croul S (a), Hawkins C (a), Hitzler J (d), Wang JC (g), Baruchel S (d), Dirks PB (a), Malkin D (b,d), Pfister S (f), Taylor MD (a), Weksberg R (b,h), Tabori U (a,d,h).

Autores e afiliações:

Castelo-Branco P (a) , Choufani S (b), Mack S (a), Gallagher D (c), Zhang C (a), Lipman T (a), Zhukova N (a) , Walker EJ(a), Martin D (a), Merino D (b), Wasserman JD (b), Elizabeth C(a), Alon N (b), Zhang L (d), Hovestadt V (e), Kool M (f), Jones DT (f), Zadeh G (a), Croul S (a), Hawkins C (a), Hitzler J (d), Wang JC (g), Baruchel S (d), Dirks PB (a), Malkin D (b,d), Pfister S (f), Taylor MD (a), Weksberg R (b,h), Tabori U (a,d,h).