Carlos Ribeiro

In this publication we report on the design and synthesis of a library of twenty-six spirotriazoline oxindoles and their in vitro evaluation as potential anticancer agents. The antiproliferative activity of the synthesized compounds was assessed against four different cancer cell lines (HCT-116 p53 ^(+/+), HCT-116 p53 ^(-/-), MCF-7, MDA-MB-231). Four spirotriazoline oxindoles showed selectivity against the four cancer cell lines tested over the non-cancer derived HEK 293T cell line.

O cancro da mama é o tipo de cancro mais comum entre as mulheres, sendo a principal causa de morte por cancro nos USA em mulheres entre os 20 e os 59 anos. Em particular, os carcinomas de mama triplo negativos são os mais agressivos e mortais, sendo extremamente importante o desenvolvimento de novos fármacos que atuem nestes subtipos de cancro da mama.