Nuno a. Fonseca

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Nucleolin overexpression in cancer stem cells enables targeted intracellular delivery of synergistic drug combination

Breast cancer stem cells (CSC) are believed to play a relevant role in tumor growth and relapse, metastization and active evasion to standard chemotherapy, thus representing an important tumor target. The objective of this work was to assess whether nucleolin was a receptor expressed in both breast cancer stem cells and non-stem cancer cells and whether it could be exploited to target nanoparticles-encapsulating drug combinations.

A sobreexpressão de nucleolina em células cancerígenas estaminais permite a entrega de combinação sinergística de fármacos

Em cancro da mama, pensa-se que existem as denominadas células estaminais cancerígenas (CEC), e que estas desempenham um papel relevante no crescimento tumoral, metastização, recorrência e resistência ativa à quimioterapia. Tais características fazem das CEC alvos terapêuticos relevantes.