Apoptosis; Breast cancer; Carcinogen; DMBA; Mammary gland; Regucalcin

Previous studies of the research group led by Professor Silvia Socorro demonstrated that regucalcin (RGN), a calcium-binding protein involved in the regulation of intracellular calcium and several signaling pathways, is under-expressed in breast cancer cases comparatively with non-neoplastic tissues. In the present study, published in the Experimental Cell Research journal, the same investigators from the Health Sciences Research Center, University of Beira Interior (CICS-UBI) identified RGN as a protective molecule in the carcinogenesis of mammary gland.

Estudos prévios do grupo de investigação liderado pela Professora Sílvia Socorro, haviam demonstrado que a regucalcina (RGN), uma proteína reguladora dos níveis de cálcio intracelular e envolvida em diversas vias de sinalização, apresenta uma expressão diminuída em casos de cancro da mama relativamente a tecidos não neoplásticos.