Recent advancements in the investigation of cancer metabolism through metabolomic approaches

send to a friend share this

Recent advancements in the investigation of cancer metabolism through metabolomic approaches

Friday, 18.10.2019

Paula Guedes de Pinho, Márcia Carvalho and Joana Pinto were recently guest editors of a Special Issue book “Cancer Metabolomics 2018”, published in Metabolites journal, focused in the recent advancements in the investigation of cancer metabolism through metabolomic approaches. The metabolome comprises the set of low molecular weight compounds present in cells, being influenced by several factors, such as diseases, lifestyle, among others. Since the metabolism of tumor cells differs from the metabolism of normal cells, this approach constitutes a powerful tool in cancer biomarker discovery aiming the improvement of cancer diagnosis and treatment.

 

Authors and Afiliations:

Paula Guedes de Pinho: UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Toxicologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

Márcia Carvalho: FP-ENAS, Universidade Fernando Pessoa, Porto, Portugal & UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Toxicologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal;

Joana Pinto: UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Toxicologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

 

Abstract:

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

 

Journal: Metabolites

 

Link: https://www.mdpi.com/journal/metabolites/special_issues/cancer_metabolomics_2018