HOTAIR Polymorphisms have implications in the prognosis of prostate cancer

Authors and Affiliations:

Ana Isabel Oliveira1,2*, Ana Xavier-Magalhães^1,2*, Catarina Moreira-Barbosa³, Hugo Magalhães^1,2, Rui Henrique^3,4,5, Carmen Jerónimo^4,5, Bruno M. Costa^1,2.

¹Life and Health Sciences Research Institute (ICVS), School of Health Sciences, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal;

²ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal;

³ Cancer Biology & Epigenetics Group - Research Center CI-IPOP, Portuguese Oncology Institute of Porto, Porto, Portugal;

⁴Department of Pathology & Molecular Immunology, Institute of Biomedical Sciences Abel Salazar - University of Porto (ICBAS-UP), Porto, Portugal;

⁵Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

* These authors contributed equally for this work.

Abstract:

Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.

Journal: Biomarkers in Medicine

Link: https://www.ncbi.nlm.nih.gov/pubmed/29436234