zebrafish

Lopes-Bastos et al. report that melanoma in zebrafish initiates without telomerase (or ALT) activation. However, in late progression, telomerase becomes essential for sustained tumor growth. Tumors that fail to re-activate telomerase slow down growth and even regress. This occurs due to tumor-autonomous (genomic instability) and non-tumor-autonomous (immune response) mechanisms.

Authors and Affiliations:

Marisa Reverendo¹, Ana R Soares¹, Patrícia M Pereira¹, Laura Carreto¹, Violeta Ferreira¹, Evelina Gatti ^{2, 3, 4}, Philippe Pierre ^{2, 3, 4}, Gabriela R Moura¹ and Manuel A S Santos^1*

¹iBiMED & Health Sciences, University of Aveiro, Portugal

² Centre d’Immunologie de Marseille-Luminy,

Aix-Marseille Université, Marseille, France

³ INSERM, Marseille, France