Researchers from two Groups of Research Center IPO Porto Cancer: Biology & Epigenetics Group and Medical Physics, Radiobiology and Radiological Protection, recently published a study in the international journal Cell Death & Disease entitled: “JmjC-KDMs KMD3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma”. This work highlights the role of lysine demethylases (KDMs), in particular KDM3A, in radioresistant behavior of esophageal squamous cell carcinoma cells, under hypoxia.