Cancer Genetics

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Animal Models of Cancer Conference

Animal Models of Cancer Conference

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

Authors and affiliations:

Bruno Silva(1), Richard Pentz(1), Ana Margarida Figueira(1), Rajika Arora(1), Yong Woo Lee(1), Charlotte Hodson(2), Harry Wischnewski(3), Andrew J. Deans(2,4), and Claus M. Azzalin(1)

(1)Instituto de Medicina Molecular João Lobo Antunes (iMM), Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649-028, Portugal

(2)Genome Stability Unit, St. Vincent’s Institute of Medical Research, Fitzroy, 3065, VIC, Australia

Novo estudo revela um mecanismo de sobrevivência inesperado de um subconjunto de células tumorais

Os tumores ALT compreendem aproximadamente 10% dos tumores humanos, desenvolvem-se maioritariamente em crianças (por exemplo, o osteossarcoma juvenil) e são particularmente resistentes à quimioterapia convencional. «Ao contrário do mecanismo canónico de alongamento dos telómeros, que ativa a enzima telomerase, essas células tumorais usam especificamente esse caminho alternativo que é insensível a abordagens terapêuticas baseadas na inibição da telomerase», explica Claus Azzalin, líder do grupo no iMM.

VII Workshop on Cancer Research Biological & Molecular Basis

i3S/Ipatimup, Meeting room 2, Porto Portugal

 

29 May - 01 June, 2017

 

See more informations here: https://www.ipatimup.pt/Site/ActivityView.aspx?ActivityId=2990

VII Workshop on Cancer Research Biological & Molecular Basis

i3S/Ipatimup, Meeting room 2, Porto Portugal

 

29 May - 01 June, 2017

 

See more informations here: https://www.ipatimup.pt/Site/ActivityView.aspx?ActivityId=2990

Spring Course in Hereditary Cancer Genetics

University Residential Centre of Bertinoro, Bertinoro, Italy

 

10 - 13 April, 2016

 

See more informations here: http://www.ceub.it/default.asp?id_c=510&id=436#.Vq-V609OfAV

Spring Course in Hereditary Cancer Genetics

University Residential Centre of Bertinoro, Bertinoro, Italy

 

10 - 13 April, 2016

 

See more informations here: http://www.ceub.it/default.asp?id_c=510&id=436#.Vq-V609OfAV

European Human Genetics Conference 2015

SECC, Glasgow, Scotland, United Kingdom

 

6-9 June, 2015

 

See more informations here: https://www.eshg.org/eshg2015.html

European Human Genetics Conference 2015

SECC, Glasgow, Scotland, United Kingdom

 

6-9 June, 2015

 

See more informations here: https://www.eshg.org/eshg2015.html