ASPIC

Cancer Research UK has launched its Grand Challenge: «the most ambitious cancer research grants in the world», worth up to £20 million (about €27 million) each. They’re intended to catalyse a revolution in how we prevent, diagnose, and treat cancer by bringing together the brightest minds around the globe, providing the freedom to undertake innovative, game-changing research.

Cancer Research UK has launched its Grand Challenge: «the most ambitious cancer research grants in the world», worth up to £20 million (about €27 million) each. They’re intended to catalyse a revolution in how we prevent, diagnose, and treat cancer by bringing together the brightest minds around the globe, providing the freedom to undertake innovative, game-changing research.

Interview with Oliver Smithies of the University of North Carolina at Chapel Hill, who was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous recombination of transgenic DNA. From the series «Conversations with Giants in Medicine», at «The Journal of Clinical Investigation».

See here all the interview: http://www.jci.org/videos/101

Interview with Oliver Smithies of the University of North Carolina at Chapel Hill, who was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous recombination of transgenic DNA. From the series «Conversations with Giants in Medicine», at «The Journal of Clinical Investigation».

See here all the interview: http://www.jci.org/videos/101

Authors and affiliations:
Maria João Ramalho, Joana Angélica Loureiro, Bárbara Gomes, Manuela Faria Frasco, Manuel Álvaro Neto Coelho e Maria do Carmo Pereira

Hereditary prostate cancer is estimated to account for 5-10% of all prostate cancer cases, but the identification of highly penetrant genes has been difficult. HOXB13 was recently identified as a susceptibility gene for prostate cancer (PrCa) when the rare, but recurrent, germline mutation [G84E, p.(Gly84Glu)] was found in men of European descent, conferring an increased PrCa risk of 4.51-fold.

Apesar de se estimar que cerca de 5-10% de todos os cancros da próstata (CaP) são de origem hereditária, a identificação de genes altamente penetrantes tem sido difícil. O gene HOXB13 foi recentemente identificado como um gene de suscetibilidade para CaP quando uma mutação rara, embora recorrente [G84E, p.(Gly84Glu)], foi reportada em homens de descendência Europeia, conferindo um risco aumentado em 4.51 vezes para o desenvolvimento da doença.

Cancer incidence will keep rising up to 2020, in the North Region of Portugal. According to the North Region Cancer Registry (RORENO), 10236 new cases will be diagnosed in that year. Women will experience the steepest increase, mainly due to thyroid and lung cancers. For the same period, a decreasing trend in the number of new cases is expected for cancer of the cervix. This study contributed to a broader understanding of the population’s cancer burden, useful for the implementation of cancer control measures.

Authors and Affiliations:

A incidência de cancro irá continuar a aumentar até 2020, na Região Norte de Portugal. Segundo projeções do Registo Oncológico Regional do Norte (RORENO), nesse ano serão diagnosticados 10.236 casos novos de cancro. Este aumento será mais acentuado na mulher, sobretudo devido ao maior número de casos do cancro da tiróide e do pulmão. Em tendência decrescente encontra-se o cancro do colo do útero, cujo número de casos prevê-se irá diminuir neste período de tempo.