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IECC 2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity

Virtual Event, Worldwide

 

14 - 16 February 2022

 

See more informations here: https://iecc2022.sciforum.net/

IECC 2022: Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity

Virtual Event, Worldwide

 

14 - 16 February 2022

 

See more informations here: https://iecc2022.sciforum.net/

EACR Conference: Cancer Genomics

Oxford Brookes University, Oxford, United Kingdom

 

5 - 7 July 2022

 

See more informations here: https://www.eacr.org/conference/cancergenomics2022?utm_source=eacrnews&utm_medium=email&utm_campaign=CG22

EACR Conference: Cancer Genomics

Oxford Brookes University, Oxford, United Kingdom

 

5 - 7 July 2022

 

See more informations here: https://www.eacr.org/conference/cancergenomics2022?utm_source=eacrnews&utm_medium=email&utm_campaign=CG22

EACR Conferences: Liquid Biopsies

Centro Congressi Giovanni XXIII, Bergamo, Italy

 

24-26 May, 2022

 

See more informations here: https://www.eacr.org/conference/liquidbiopsies2022/index

 

 

EACR Conferences: Liquid Biopsies

Centro Congressi Giovanni XXIII, Bergamo, Italy

 

24-26 May, 2022

 

See more informations here: https://www.eacr.org/conference/liquidbiopsies2022/index

 

 

12th Innovation in Breast Cancer symposium

Online

 

17-18 February, 2022

 

See more informations here: https://www.doctaforum.org/2022/ibc2022/presentacion/

12th Innovation in Breast Cancer symposium

Online

 

17-18 February, 2022

 

See more informations here: https://www.doctaforum.org/2022/ibc2022/presentacion/

Disruption of breast cancer cell pH dynamics decreases aggressiveness and potentiates response to chemotherapy

The reverse pH gradient is a common feature of cancer cells, in which the intracellular pH is more alkaline and the extracellular more acidic. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium–proton exchangers (NHEs). In this work, we analyzed the expression of these pH regulators and explored their inhibition in breast cancer cells as a therapeutic strategy.

A disrupção do controlo do pH das células de cancro da mama diminui a agressividade e potencia a resposta à quimioterapia

O gradiente reverso de pH é uma característica comum das células malignas, em que o pH intracelular é mais alcalino e o extracelular mais acídico, fator que está associado a uma maior agressividade. As células malignas conseguem manter este gradiente de pH à custa da atividade aumentada de várias proteínas reguladoras de pH (proteínas membranares), como sejam as ATPases, anidrases carbónicas (CAs), transportadores de monocarboxilatos (MCTs) e os trocadores sódio–protão (NHEs).