Patrícia S. Guerreiro

The work entitled «Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxicity in MDA-MB-231 human breast cancer cells» addresses the study of DNA repair inhibitors. These compounds have been developed as potential therapeutic agents for the enhancement of the chemotherapy efficacy. In this article, we assessed the effects of methoxyamine in the cytotoxicity and genotoxicity induced by doxorubicin in MDA-MB-231 breast cancer cells. Methoxyamine is an indirect inhibitor of APE1 enzyme involved in base excision repair (BER) pathway.

O trabalho intitulado «Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxicity in MDA-MB-231 human breast cancer cells» insere-se no âmbito do estudo de inibidores da reparação de lesões do DNA. Estes compostos têm sido desenvolvidos como potenciais agentes terapêuticos com o objectivo de aumentar a eficácia da quimioterapia. Neste artigo, avaliámos os efeitos da metoxiamina na citotoxicidade e genotoxicidade induzida pela doxorrubicina em células de cancro de mama MDA-MB-231.